The Enzyme Database

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EC 3.1.3.101     
Accepted name: validoxylamine A 7′-phosphate phosphatase
Reaction: validoxylamine A 7′-phosphate + H2O = validoxylamine A + phosphate
For diagram of validamycin biosynthesis, click here
Glossary: validoxylamine A = (1S,2S,3R,6S)-4-(hydroxymethyl)-6-{[(1S,2S,3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}cyclohex-4-ene-1,2,3-triol
Other name(s): vldH (gene name)
Systematic name: validoxylamine-A 7′-phosphate phosphohydrolase
Comments: The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Asamizu, S., Yang, J., Almabruk, K.H. and Mahmud, T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J. Am. Chem. Soc. 133 (2011) 12124–12135. [PMID: 21766819]
[EC 3.1.3.101 created 2016]
 
 


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