| EC |
3.1.3.101 |
| Accepted name: |
validoxylamine A 7′-phosphate phosphatase |
| Reaction: |
validoxylamine A 7′-phosphate + H2O = validoxylamine A + phosphate |
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For diagram of validamycin biosynthesis, click here |
| Glossary: |
validoxylamine A = (1S,2S,3R,6S)-4-(hydroxymethyl)-6-{[(1S,2S,3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}cyclohex-4-ene-1,2,3-triol |
| Other name(s): |
vldH (gene name) |
| Systematic name: |
validoxylamine-A 7′-phosphate phosphohydrolase |
| Comments: |
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Asamizu, S., Yang, J., Almabruk, K.H. and Mahmud, T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J. Am. Chem. Soc. 133 (2011) 12124–12135. [DOI] [PMID: 21766819] |
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| [EC 3.1.3.101 created 2016] |
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