The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 3.1.3.100     
Accepted name: thiamine phosphate phosphatase
Reaction: thiamine phosphate + H2O = thiamine + phosphate
Systematic name: thiamine phosphate phosphohydrolase
Comments: The enzyme participates in the thiamine biosynthesis pathway in eukaryotes and a few prokaryotes. These organisms lack EC 2.7.4.16, thiamine-phosphate kinase, and need to convert thiamine phosphate to thiamine diphosphate, the active form of the vitamin, by first removing the phosphate group, followed by diphosphorylation by EC 2.7.6.2, thiamine diphosphokinase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Sanemori, H., Egi, Y. and Kawasaki, T. Pathway of thiamine pyrophosphate synthesis in Micrococcus denitrificans. J. Bacteriol. 126 (1976) 1030–1036. [PMID: 181359]
2.  Komeda, Y., Tanaka, M. and Nishimune, T. A th-1 mutant of Arabidopsis thaliana is defective for a thiamin-phosphate-synthesizing enzyme: thiamin phosphate pyrophosphorylase. Plant Physiol. 88 (1988) 248–250. [PMID: 16666289]
3.  Schweingruber, A.M., Dlugonski, J., Edenharter, E. and Schweingruber, M.E. Thiamine in Schizosaccharomyces pombe: dephosphorylation, intracellular pool, biosynthesis and transport. Curr. Genet. 19 (1991) 249–254. [PMID: 1868574]
4.  Muller, I.B., Bergmann, B., Groves, M.R., Couto, I., Amaral, L., Begley, T.P., Walter, R.D. and Wrenger, C. The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels. PLoS One 4:e7656 (2009). [PMID: 19888457]
5.  Kolos, I.K. and Makarchikov, A.F. [Identification of thiamine monophosphate hydrolyzing enzymes in chicken liver] Ukr Biochem J 86 (2014) 39–49. [PMID: 25816604] (in Russian)
6.  Mimura, M., Zallot, R., Niehaus, T.D., Hasnain, G., Gidda, S.K., Nguyen, T.N., Anderson, E.M., Mullen, R.T., Brown, G., Yakunin, A.F., de Crecy-Lagard, V., Gregory, J.F., 3rd, McCarty, D.R. and Hanson, A.D. Arabidopsis TH2 encodes the orphan enzyme thiamin monophosphate phosphatase. Plant Cell 28 (2016) 2683–2696. [PMID: 27677881]
[EC 3.1.3.100 created 2016]
 
 


Data © 2001–2017 IUBMB
Web site © 2005–2017 Andrew McDonald