The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 3.1.21.3     
Accepted name: type I site-specific deoxyribonuclease
Reaction: Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5′-phosphates; ATP is simultaneously hydrolysed
Other name(s): type I restriction enzyme; deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent); restriction-modification system; deoxyribonuclease (adenosine triphosphate-hydrolyzing); adenosine triphosphate-dependent deoxyribonuclease; ATP-dependent DNase; type 1 site-specific deoxyribonuclease
Comments: This is a large group of enzymes which, together with those now listed as EC 3.1.21.4 (type II site-specific deoxyribonuclease) and EC 3.1.21.5 (type III site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC 3.1.23 and EC 3.1.24. They have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. They are multifunctional proteins that also catalyse the reactions of EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] and EC 2.1.1.37
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37263-09-5
References:
1.  Roberts, R.J. Restriction enzymes and their isoschizomers. Nucleic Acids Res. 18 (1990) 2331–2365. [PMID: 2159140]
[EC 3.1.21.3 created 1984 from EC 3.1.23 and EC 3.1.24]
 
 


Data © 2001–2014 IUBMB
Web site © 2005–2014 Andrew McDonald