The Enzyme Database

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EC 3.1.21.1     
Accepted name: deoxyribonuclease I
Reaction: Endonucleolytic cleavage to 5′-phosphodinucleotide and 5′-phosphooligonucleotide end-products
Other name(s): pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; DNase I; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease
Comments: Preference for double-stranded DNA.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9003-98-9
References:
1.  Privat de Garilhe, M. and Laskowski, M. Study of the enzymatic degradation of deoxyribonucleic acid by two different deoxyribonucleodepolymerases. J. Biol. Chem. 215 (1955) 269–276. [PMID: 14392161]
2.  Kunitz, M. Isolation of crystalline deoxyribonuclease from beef pancreas. Science 108 (1948) 19–20.
3.  Laskowski, M. , Sr. Venom exonuclease. In: Boyer, P.D. (Ed.), The Enzymes, 3rd edn, vol. 4, Academic Press, New York, 1971, pp. 313–328.
[EC 3.1.21.1 created 1961 as EC 3.1.4.5, transferred 1978 to EC 3.1.21.1, modified 1981]
 
 


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