EC |
3.1.2.22 |
Accepted name: |
palmitoyl[protein] hydrolase |
Reaction: |
palmitoyl[protein] + H2O = palmitate + protein |
Other name(s): |
palmitoyl-protein thioesterase; palmitoyl-(protein) hydrolase |
Systematic name: |
palmitoyl[protein] hydrolase |
Comments: |
Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 150605-49-5 |
References: |
1. |
Camp, L.A., Hofmann, S.L. Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate. Methods Enzymol. 250 (1995) 336–347. [DOI] [PMID: 7651163] |
2. |
Schriner, J.E., Yi, W., Hofmann, S.L. cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis. Genomics 34 (1996) 317–322. [DOI] [PMID: 8786130] |
3. |
Verkruyse, L.A., Hofmann, S.L. Lysosomal targeting of palmitoyl-protein thioesterase. J. Biol. Chem. 271 (1996) 15831–15836. [DOI] [PMID: 8663305] |
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[EC 3.1.2.22 created 1999] |
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