The Enzyme Database

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EC 3.1.11.5     
Accepted name: exodeoxyribonuclease V
Reaction: Exonucleolytic cleavage (in the presence of ATP) in either 5′- to 3′- or 3′- to 5′-direction to yield 5′-phosphooligonucleotides
Other name(s): Escherichia coli exonuclease V; E. coli exonuclease V; gene recBC endoenzyme; RecBC deoxyribonuclease; gene recBC DNase; exonuclease V; gene recBCD enzymes
Comments: Preference for double-stranded DNA. Possesses DNA-dependent ATPase activity. Acts endonucleolytically on single-stranded circular DNA.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37350-26-8
References:
1.  Eichler, D.C. and Lehman, I.R. On the role of ATP in phosphodiester bond hydrolysis catalyzed by the recBC deoxyribonuclease of Escherichia coli. J. Biol. Chem. 252 (1977) 499–503. [PMID: 319095]
2.  Goldmark, P.J. and Liun, S. Purification and properties of the recBC DNase of Escherichia coli K-12. J. Biol. Chem. 247 (1972) 1849–1860. [PMID: 4552016]
3.  Oishi, M. An ATP-dependent deoxyribonuclease from Escherichia coli with a possible role in genetic recombination. Proc. Natl. Acad. Sci. USA 64 (1969) 1292–1299. [PMID: 4916924]
4.  Wright, M., Buttin, G. and Hurwitz, J. The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes. J. Biol. Chem. 246 (1971) 6543–6555. [PMID: 4332130]
[EC 3.1.11.5 created 1978]
 
 


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