The Enzyme Database

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EC 3.1.11.2     
Accepted name: exodeoxyribonuclease III
Reaction: Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates
Other name(s): Escherichia coli exonuclease III; E. coli exonuclease III; endoribonuclease III
Comments: Preference for double-stranded DNA. Has endonucleolytic activity near apurinic sites on DNA.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9037-44-9
References:
1.  Lindahl, T., Gally, J.A. and Edelman, G.M. Properties of deoxyribonuclease 3 from mammalian tissues. J. Biol. Chem. 244 (1969) 5014–5019. [PMID: 5824576]
2.  Richardson, C.C. and Kornberg, A. A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity. J. Biol. Chem. 239 (1964) 242–250. [PMID: 14114850]
3.  Richardson, C.C., Lehman, I.R. and Kornberg, A. A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. II. Characterization of the exonuclease activity. J. Biol. Chem. 239 (1964) 251–258. [PMID: 14114851]
[EC 3.1.11.2 created 1972 as EC 3.1.4.27, transferred 1978 to EC 3.1.11.2]
 
 


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