All-trans-retinyl esters, which are a storage form of vitamin A, are generated by the activity of EC 18.104.22.168, phosphatidylcholine—retinol O-acyltransferase (LRAT). They can be hydrolysed to 11-cis-retinol by EC 22.214.171.124, retinoid isomerohydrolase (RPE65), or to 13-cis-retinol by this enzyme.
Takahashi, Y., Moiseyev, G., Chen, Y., Farjo, K., Nikolaeva, O. and Ma, J.X. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J.278 (2011) 973–987. [DOI] [PMID: 21235714]