The Enzyme Database

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EC 3.1.1.90     
Accepted name: all-trans-retinyl ester 13-cis isomerohydrolase
Reaction: an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid
For diagram of retinal and derivatives biosynthesis, click here
Systematic name: all-trans-retinyl ester acylhydrolase, 13-cis retinol forming
Comments: All-trans-retinyl esters, which are a storage form of vitamin A, are generated by the activity of EC 2.3.1.135, phosphatidylcholine—retinol O-acyltransferase (LRAT). They can be hydrolysed to 11-cis-retinol by EC 3.1.1.64, retinoid isomerohydrolase (RPE65), or to 13-cis-retinol by this enzyme.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Takahashi, Y., Moiseyev, G., Chen, Y., Farjo, K., Nikolaeva, O. and Ma, J.X. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J. 278 (2011) 973–987. [PMID: 21235714]
[EC 3.1.1.90 created 2011]
 
 


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