ExplorEnz: EC 3.1.1.4*

Your query returned 11 entries. Printable version

3.1.1.4

Accepted name:

phospholipase A₂

Reaction:

phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate

Other name(s):

lecithinase A; phosphatidase; phosphatidolipase; phospholipase A

Systematic name:

phosphatidylcholine 2-acylhydrolase

Comments:

Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca²⁺.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9001-84-7

References:

1.	Doery, H.M. and Pearson, J.E. Haemolysins in venoms of Australian snakes. Observations on the haemolysins of the venoms of some Australian snakes and the separation of phospholipase A from the venom of Pseudechis porphyriacus. Biochem. J. 78 (1961) 820–827. [PMID: 13723433]
2.	Fraenkel-Conrat, H. and Fraenkel-Conrat, J. Inactivation of crotoxin by group-specific reagents. Biochim. Biophys. Acta 5 (1950) 98–104. [DOI] [PMID: 15433984]
3.	Hanahan, D.J., Brockerhoff, H. and Barron, E.J. The site of attack of phospholipase (lecithinase) A on lecithin: a re-evaluation. Position of fatty acids on lecithins and triglycerides. J. Biol. Chem. 235 (1960) 1917–1923. [PMID: 14399412]
4.	Moore, J.H. and Williams, D.L. Some observations on the specificity of phospholipase A. Biochim. Biophys. Acta 84 (1964) 41–54. [PMID: 14124755]
5.	Saito, K. and Hanahan, D.J. A study of the purification and properties of the phospholipase A of Crotalus adamanteus venom. Biochemistry 1 (1962) 521–532. [PMID: 14496116]
6.	van den Bosch, H. Intracellular phospholipases A. Biochim. Biophys. Acta 604 (1980) 191–246. [DOI] [PMID: 6252969]

[EC 3.1.1.4 created 1961, modified 1976, modified 1983]

3.1.1.40

Accepted name:

orsellinate-depside hydrolase

Reaction:

orsellinate depside + H₂O = 2 orsellinate

Glossary:

orsellinate = 2,4-dihydroxy-6-methylbenzoate

Other name(s):

lecanorate hydrolase

Systematic name:

orsellinate-depside hydrolase

Comments:

The enzyme will only hydrolyse those substrates based on the 2,4-dihydroxy-6-methylbenzoate structure that also have a free hydroxy group ortho to the depside linkage.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 62213-12-1

References:

1.	Schultz, J. and Mosbach, K. Studies on lichen enzymes. Purification and properties of an orsellinate depside hydrolase obtained from Lasallia pustulata. Eur. J. Biochem. 22 (1971) 153–157. [DOI] [PMID: 5116606]

[EC 3.1.1.40 created 1976]

3.1.1.41

Accepted name:

cephalosporin-C deacetylase

Reaction:

cephalosporin C + H₂O = deacetylcephalosporin C + acetate

For diagram of cephalosporin biosynthesis, click here

Other name(s):

cephalosporin C acetyl-hydrolase; cephalosporin C acetylase; cephalosporin acetylesterase; cephalosporin C acetylesterase; cephalosporin C acetyl-esterase; cephalosporin C deacetylase

Systematic name:

cephalosporin-C acetylhydrolase

Comments:

Hydrolyses the acetyl ester bond on the 10-position of the antibiotic cephalosporin C.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 52227-71-1

References:

1.	Fujisawa, Y., Shirafuji, H., Kida, M. and Nara, K. New findings on cephalosporin C biosynthesis. Nat. New Biol. 246 (1973) 154–155. [PMID: 4519146]

[EC 3.1.1.41 created 1976]

3.1.1.42

Accepted name:

chlorogenate hydrolase

Reaction:

chlorogenate + H₂O = caffeate + quinate

Other name(s):

chlorogenase; chlorogenic acid esterase

Systematic name:

chlorogenate hydrolase

Comments:

Also acts, more slowly, on isochlorogenate. No other substrates are known.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 74082-59-0

References:

1.	Schöbel, B. and Pollmann, W. Isolation and characterization of a chlorogenic acid esterase from Aspergillus niger. Z. Naturforsch. C: Biosci. 35 (1980) 209–212. [PMID: 7385941]
2.	Schöbel, B. and Pollmann, W. Weitere Charakterisierung einer Chlorogensäure - Hydrolase aus Aspergillus niger. Z. Naturforsch. C: Biosci. 35 (1980) 699–701. [PMID: 7445677]

[EC 3.1.1.42 created 1981]

3.1.1.43

Accepted name:

α-amino-acid esterase

Reaction:

an α-amino acid ester + H₂O = an α-amino acid + an alcohol

Other name(s):

α-amino acid ester hydrolase

Systematic name:

α-amino-acid-ester aminoacylhydrolase

Comments:

Also catalyses α-aminoacyl transfer to a number of amine nucleophiles.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 74506-40-4

References:

1.	Kato, K., Kawahara, K., Takahashi, T. and Kakinuma, A. Purification of an α-amino acid ester hydrolase from Xanthomonas citri. Agric. Biol. Chem. 44 (1980) 1069–1074.
2.	Kato, K., Kawahara, K., Takahashi, T. and Kakinuma, A. Substrate specificity of an α-amino acid ester hydrolase from Xanthomonas citri. Agric. Biol. Chem. 44 (1980) 1075–1081.
3.	Takahashi, T., Yamazaki, Y. and Kato, K. Substrate specificity of an α-amino acid ester hydrolase produced by Acetobacter turbidans A. T.C.C. 9325. Biochem. J. 137 (1974) 497–503. [PMID: 4424889]

[EC 3.1.1.43 created 1983]

3.1.1.44

Accepted name:

4-methyloxaloacetate esterase

Reaction:

oxaloacetate 4-methyl ester + H₂O = oxaloacetate + methanol

Systematic name:

oxaloacetate-4-methyl-ester oxaloacetohydrolase

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 74812-46-7

References:

1.	Donnelly, M.I. and Dagley, S. Production of methanol from aromatic acids by Pseudomonas putida. J. Bacteriol. 142 (1980) 916–924. [PMID: 7380811]

[EC 3.1.1.44 created 1983]

3.1.1.45

Accepted name:

carboxymethylenebutenolidase

Reaction:

4-carboxymethylenebut-2-en-4-olide + H₂O = 4-oxohex-2-enedioate

Other name(s):

maleylacetate enol-lactonase; dienelactone hydrolase; carboxymethylene butenolide hydrolase

Systematic name:

4-carboxymethylenebut-2-en-4-olide lactonohydrolase

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 76689-22-0

References:

1.	Schmidt, E. and Knackmuss, H.-J. Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. Biochem. J. 192 (1980) 339–347. [PMID: 7305906]

[EC 3.1.1.45 created 1983]

3.1.1.46

Accepted name:

deoxylimonate A-ring-lactonase

Reaction:

deoxylimonate + H₂O = deoxylimononic acid D-ring-lactone

Systematic name:

deoxylimonate A-ring-lactonohydrolase

Comments:

The enzyme opens the A-ring-lactone of the triterpenoid deoxylimonic acid, leaving the D-ring-lactone intact.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 75788-82-8

References:

1.	Hasegawa, H., Bennett, R.D. and Verdon, C.P. Metabolism of limonoids via a deoxylimonoid pathway in Citrus. Phytochemistry 19 (1980) 1445–1447.

[EC 3.1.1.46 created 1983]

3.1.1.47

Accepted name:

1-alkyl-2-acetylglycerophosphocholine esterase

Reaction:

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H₂O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

Other name(s):

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase; alkylacetyl-GPC:acetylhydrolase

Systematic name:

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 76901-00-3

References:

1.	Blank, M.L., Lee, T.-C., Fitzgerald, V. and Snyder, F. A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid). J. Biol. Chem. 256 (1981) 175–178. [PMID: 7451433]

[EC 3.1.1.47 created 1984]

3.1.1.48

Accepted name:

fusarinine-C ornithinesterase

Reaction:

N⁵-acyl-L-ornithine ester + H₂O = N⁵-acyl-L-ornithine + an alcohol

Other name(s):

ornithine esterase; 5-N-acyl-L-ornithine-ester hydrolase

Systematic name:

N⁵-acyl-L-ornithine-ester hydrolase

Comments:

Hydrolyses the three ornithine ester bonds in fusarinine C. Also acts on N⁵-dinitrophenyl-L-ornithine methyl ester.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 60202-10-0

References:

1.	Emery, T. Fungal ornithine esterases: relationship to iron transport. Biochemistry 15 (1976) 2723–2728. [PMID: 949472]

[EC 3.1.1.48 created 1984]

3.1.1.49

Accepted name:

sinapine esterase

Reaction:

sinapoylcholine + H₂O = sinapate + choline

Other name(s):

aromatic choline esterase

Systematic name:

sinapoylcholine sinapohydrolase

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 72506-67-3

References:

1.	Nurmann, G. and Strack, D. Sinapine esterase. 1. Characterization of sinapine esterase from cotyledons of Raphanus sativus. Z. Naturforsch. C: Biosci. 34 (1979) 715–720.

[EC 3.1.1.49 created 1984]