The Enzyme Database

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EC 2.8.4.2     
Accepted name: arsenate-mycothiol transferase
Reaction: arsenate + mycothiol = arseno-mycothiol + H2O
Glossary: mycothiol = 1-O-[2-(N2-acetyl-L-cysteinamido)-2-deoxy--D-glucopyranosyl]-1D-myo-inositol
Other name(s): ArsC1; ArsC2; mycothiol:arsenate transferase
Systematic name: mycothiol:arsenate S-arsenotransferase
Comments: Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Ordonez, E., Van Belle, K., Roos, G., De Galan, S., Letek, M., Gil, J.A., Wyns, L., Mateos, L.M. and Messens, J. Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange. J. Biol. Chem. 284 (2009) 15107–15116. [PMID: 19286650]
[EC 2.8.4.2 created 2010]
 
 


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