| EC |
2.8.3.22 |
| Accepted name: |
succinyl-CoA—L-malate CoA-transferase |
| Reaction: |
(1) succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA
(2) succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA |
| Glossary: |
(S)-citramalate = (2S)-2-hydroxy-2-methylbutanedioate
(S)-malate = (2S)-2-hydroxybutanedioate
(S)-malyl-CoA = (3S)-3-carboxy-3-hydroxypropanoyl-CoA |
| Other name(s): |
SmtAB |
| Systematic name: |
succinyl-CoA:(S)-malate CoA-transferase |
| Comments: |
The enzyme, purified from the bacterium Chloroflexus aurantiacus, can also accept itaconate as acceptor, with lower efficiency. It is part of the 3-hydroxypropanoate cycle for carbon assimilation. |
| References: |
| 1. |
Friedmann, S., Steindorf, A., Alber, B.E. and Fuchs, G. Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. J. Bacteriol. 188 (2006) 2646–2655. [PMID: 16547052] |
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| [EC 2.8.3.22 created 2014] |
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