| EC |
2.8.3.15 |
| Accepted name: |
succinyl-CoA:(R)-benzylsuccinate CoA-transferase |
| Reaction: |
succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA |
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For diagram of anaerobic toluene catabolism, click here |
| Other name(s): |
benzylsuccinate CoA-transferase |
| Systematic name: |
succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase |
| Comments: |
Involved in anaerobic catabolism of toluene and is a strictly toluene-induced enzyme that catalyses the reversible regio- and enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA. The enzyme from Thauera aromatica is inactive when (R)-benzylsuccinate is replaced by (S)-benzylsuccinate. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 260966-56-1 |
| References: |
| 1. |
Leutwein, C. and Heider, J. Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria. J. Bacteriol. 183 (2001) 4288–4295. [DOI] [PMID: 11418570] |
| 2. |
Leutwein, C. and Heider, J. Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and β-oxidation of the first intermediate, (R)-(+)-benzylsuccinate. Microbiology 145 (1999) 3265–3271. [DOI] [PMID: 10589736] |
| 3. |
Leuthner, B. and Heider, J. Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of β oxidation of the intermediate benzylsuccinate. J. Bacteriol. 182 (2000) 272–277. [DOI] [PMID: 10629170] |
| 4. |
Heider, J. A new familiy of CoA-transferases. FEBS Lett. 509 (2001) 345–349. [DOI] [PMID: 11749953] |
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| [EC 2.8.3.15 created 2003] |
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