| EC |
2.8.2.8 |
| Accepted name: |
[heparan sulfate]-glucosamine N-sulfotransferase |
| Reaction: |
3′-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3′,5′-bisphosphate + [heparan sulfate]-N-sulfoglucosamine |
| Glossary: |
3′-phosphoadenylyl sulfate = PAPS |
| Other name(s): |
heparin N-sulfotransferase; 3′-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase; PAPS:N-desulfoheparin sulfotransferase; PAPS:DSH sulfotransferase; N-HSST; N-heparan sulfate sulfotransferase; heparan sulfate N-deacetylase/N-sulfotransferase; heparan sulfate 2-N-sulfotransferase; heparan sulfate N-sulfotransferase; heparan sulfate sulfotransferase; N-desulfoheparin sulfotransferase; desulfoheparin sulfotransferase; 3′-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase; heparitin sulfotransferase; 3′-phosphoadenylyl-sulfate:heparitin N-sulfotransferase; 3′-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase |
| Systematic name: |
3′-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfonotransferase |
| Comments: |
The enzyme also catalyses the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9026-75-9 |
| References: |
| 1. |
Suzuki, S., Trenn, R.H. and Strominger, J.L. Separation of specific mucopolysaccharide sulfotransferases. Biochim. Biophys. Acta 50 (1961) 169–174. |
| 2. |
Eisenman, R.A., Balasubramanian, A.S. and Marx, W. 3′-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction. Arch. Biochem. Biophys. 119 (1967) 387–397. [PMID: 4964017] |
| 3. |
Johnson, A.H. and Baker, J.R. The enzymatic sulphation of heparan sulphate by hen's uterus. Biochim. Biophys. Acta 320 (1973) 341–351. [DOI] [PMID: 4270798] |
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| [EC 2.8.2.8 created 1972, modified 2001 (EC 2.8.2.12 created 1972, incorporated 2001)] |
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