The Enzyme Database

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EC 2.8.2.5     
Accepted name: chondroitin 4-sulfotransferase
Reaction: 3′-phosphoadenylyl sulfate + chondroitin = adenosine 3′,5′-bisphosphate + chondroitin 4′-sulfate
For diagram of chondroitin biosynthesis (later stages), click here
Glossary: 3′-phosphoadenylyl sulfate = PAPS
Other name(s): chondroitin sulfotransferase
Systematic name: 3′-phosphoadenylyl-sulfate:chondroitin 4′-sulfotransferase
Comments: The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 83589-04-2
References:
1.  Habuchi, O. and Miyashita, N. Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage. Biochim. Biophys. Acta 717 (1982) 414–421. [PMID: 6957247]
2.  Nakanishi, Y., Otsu, K. and Suzuki, S. Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine. FEBS Lett. 151 (1983) 15–18. [PMID: 6130977]
3.  Nakanishi, Y., Shimizu, M., Otsu, K., Kato, S., Tsuji, M. and Suzuki, S. A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate. J. Biol. Chem. 256 (1981) 5443–5449. [PMID: 6787041]
4.  Suzuki, S. and Strominger, J.L. Enzymatic sulfation of mucopolysaccharides in hen oviduct. I. Transfer of sulfate from 3′-phosphoadenosine 5′-phosphosulfate to mucopolysaccharides. J. Biol. Chem. 235 (1960) 257–266. [PMID: 13835879]
5.  Suzuki, S. and Strominger, J.L. Enzymatic sulfation of mucopolysaccharides in hen oviduct. II. Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors. J. Biol. Chem. 235 (1960) 267–273. [PMID: 13835880]
6.  Suzuki, S. and Strominger, J.L. Enzymatic sulfation of mucopolysaccharides in hen oviduct. III. Mechanism of sulfation of chondroitin and chondroitin sulfate A. J. Biol. Chem. 235 (1960) 274–276. [PMID: 13835881]
[EC 2.8.2.5 created 1965, modified 1986]
 
 


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