| EC |
2.8.2.40 |
| Accepted name: |
ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase |
| Reaction: |
3′-phosphoadenylyl sulfate + ω-hydroxy-β-dihydromenaquinone-9 = adenosine 3′,5′-bisphosphate + ω-sulfo-β-dihydromenaquinone-9 |
| Glossary: |
β-dihydromenaquinone-9 = MK-9(II-H2) = 2-methyl-3-[(2E,10E,14E,18E,22E,26E,30E,33E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,10,14,18,22,26,30,33-octaen-1-yl]naphthalene-1,4-dione |
| Other name(s): |
stf3 (gene name) |
| Systematic name: |
3′-phosphoadenylyl-sulfate:ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase |
| Comments: |
The enzyme catalyses the last step in the production of ω-sulfo-β-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Mougous, J.D., Senaratne, R.H., Petzold, C.J., Jain, M., Lee, D.H., Schelle, M.W., Leavell, M.D., Cox, J.S., Leary, J.A., Riley, L.W. and Bertozzi, C.R. A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 103 (2006) 4258–4263. [PMID: 16537518] |
| 2. |
Holsclaw, C.M., Sogi, K.M., Gilmore, S.A., Schelle, M.W., Leavell, M.D., Bertozzi, C.R. and Leary, J.A. Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis. ACS Chem. Biol. 3 (2008) 619–624. [PMID: 18928249] |
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| [EC 2.8.2.40 created 2021] |
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