| EC |
2.8.2.35 |
| Accepted name: |
dermatan 4-sulfotransferase |
| Reaction: |
3′-phospho-5′-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine = adenosine 3′,5′-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine |
| Other name(s): |
dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase; dermatan-4-sulfotransferase-1; dermatan-4-sulfotransferase 1; D4ST-1; dermatan N-acetylgalactosamine 4-O-sulfotransferase; CHST14 protein; CHST14; 3′-phospho-5′-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfotransferase |
| Systematic name: |
3′-phospho-5′-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfonotransferase |
| Comments: |
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAα(1,3)GalNAcβ(1,4) that is flanked by GlcUAβ(1,3)GalNAcβ(1,4) as compared with IdoUAα(1,3)GalNAcβ(1,4) flanked by IdoUAα(1,3)GalNAcβ(1,4) [1]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Evers, M.R., Xia, G., Kang, H.G., Schachner, M. and Baenziger, J.U. Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. J. Biol. Chem. 276 (2001) 36344–36353. [DOI] [PMID: 11470797] |
| 2. |
Mikami, T., Mizumoto, S., Kago, N., Kitagawa, H. and Sugahara, K. Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis. J. Biol. Chem. 278 (2003) 36115–36127. [DOI] [PMID: 12847091] |
| 3. |
Pacheco, B., Maccarana, M. and Malmstrom, A. Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate. Glycobiology 19 (2009) 1197–1203. [DOI] [PMID: 19661164] |
| 4. |
Mitsunaga, C., Mikami, T., Mizumoto, S., Fukuda, J. and Sugahara, K. Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases. J. Biol. Chem. 281 (2006) 18942–18952. [DOI] [PMID: 16702220] |
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| [EC 2.8.2.35 created 2010] |
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