| EC |
2.8.2.21 |
| Accepted name: |
keratan sulfotransferase |
| Reaction: |
3′-phosphoadenylyl sulfate + keratan = adenosine 3′,5′-bisphosphate + keratan 6′-sulfate |
| Glossary: |
3′-phosphoadenylyl sulfate = PAPS |
| Other name(s): |
3′-phosphoadenylyl keratan sulfotransferase; keratan sulfate sulfotransferase; 3′-phosphoadenylylsulfate:keratan sulfotransferase; 3′-phosphoadenylyl-sulfate:keratan 6′-sulfotransferase |
| Systematic name: |
3′-phosphoadenylyl-sulfate:keratan 6′-sulfonotransferase |
| Comments: |
Sulfation takes place at the 6-position of galactosyl and N-acetylglucosaminyl residues in keratan, a proteoglycan. Not identical with EC 2.8.2.5 (chondroitin 4-sulfotransferase), EC 2.8.2.6 (choline sulfotransferase) or EC 2.8.2.17 (chondroitin 6-sulfotransferase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 62168-79-0 |
| References: |
| 1. |
Ruter, E.-R. and Kresse, H. Partial purification and characterization of 3′-phosphoadenylylsulfate:keratan sulfate sulfotransferases. J. Biol. Chem. 259 (1984) 11771–11776. [PMID: 6592165] |
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| [EC 2.8.2.21 created 1989] |
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