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Your query returned 1 entry. 
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| EC | 2.8.2.14 | ||||||||
| Accepted name: | bile-salt sulfotransferase | ||||||||
| Reaction: | (1) 3′-phosphoadenylyl sulfate + glycolithocholate = adenosine 3′,5′-bisphosphate + glycolithocholate 3-sulfate (2) 3′-phosphoadenylyl sulfate + taurolithocholate = adenosine 3′,5′-bisphosphate + taurolithocholate sulfate |
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| For diagram of reaction, click here and for diagram of cholic acid conjugates biosynthesis, click here | |||||||||
| Glossary: | glycolithocholate 3-sulfate = N-(3α-sulfooxy-5β-cholan-24-oyl)glycine | ||||||||
| Other name(s): | BAST I; bile acid:3′-phosphoadenosine-5′-phosphosulfate sulfotransferase; bile salt:3′phosphoadenosine-5′-phosphosulfate:sulfotransferase; bile acid sulfotransferase I; glycolithocholate sulfotransferase; 3′-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase | ||||||||
| Systematic name: | 3′-phosphoadenylyl-sulfate:glycolithocholate sulfonotransferase | ||||||||
| Comments: | The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5β-bile acid glycolithocholate, deoxycholate, 3β-hydroxy-5-cholenoate and dehydroepiandrosterone (3β-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3]. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 65802-92-8 | ||||||||
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