The Enzyme Database

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EC 2.8.1.14     
Accepted name: tRNA-5-taurinomethyluridine 2-sulfurtransferase
Reaction: a [protein]-S-sulfanyl-L-cysteine + 5-taurinomethyluracil34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 5-taurinomethyl-2-thiouracil34 in tRNA + AMP + diphosphate + acceptor
Other name(s): MTU1 (gene name); SLM3 (gene name); MTO2 (gene name)
Systematic name: [protein]-S-sulfanyl-L-cysteine:tRNA (5-taurinomethyluracil34 2-O)-sulfurtransferase
Comments: The enzyme, found in mitochondria, catalyses formation of 5-taurinomethyl-2-thiouridine in the wobble position of mitochondrial tRNAGln, tRNALys and tRNAGlu.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Umeda, N., Suzuki, T., Yukawa, M., Ohya, Y., Shindo, H., Watanabe, K. and Suzuki, T. Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J. Biol. Chem. 280 (2005) 1613–1624. [PMID: 15509579]
2.  Wang, X., Yan, Q. and Guan, M.X. Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. FEBS Lett. 581 (2007) 4228–4234. [PMID: 17706197]
[EC 2.8.1.14 created 2015]
 
 


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