ExplorEnz: EC 2.7.7.86

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2.7.7.86

Accepted name:

cyclic GMP-AMP synthase

Reaction:

ATP + GTP = 2 diphosphate + cyclic Gp(2′-5′)Ap(3′-5′) (overall reaction)
(1a) ATP + GTP = pppGp(2′-5′)A + diphosphate
(1b) pppGp(2′-5′)A = cyclic Gp(2′-5′)Ap(3′-5′) + diphosphate

Glossary:

cyclic Gp(2′-5′)Ap(3′-5′) = cyclo[(3′→5′)-guanylyl-(2′→5′)-adenylyl]

Other name(s):

cGAMP synthase; cGAS

Systematic name:

ATP:GTP adenylyltransferase (cyclizing)

Comments:

Cyclic Gp(2′-5′)Ap(3′-5′) is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Sun, L., Wu, J., Du, F., Chen, X. and Chen, Z.J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339 (2013) 786–791. [DOI] [PMID: 23258413]
2.	Ablasser, A., Goldeck, M., Cavlar, T., Deimling, T., Witte, G., Rohl, I., Hopfner, K.P., Ludwig, J. and Hornung, V. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING. Nature 498 (2013) 380–384. [DOI] [PMID: 23722158]

[EC 2.7.7.86 created 2013, modified 2014]