| EC |
2.7.7.85 |
| Accepted name: |
diadenylate cyclase |
| Reaction: |
2 ATP = 2 diphosphate + cyclic di-3′,5′-adenylate |
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For diagram of cyclic di-3′,5′-adenylate biosynthesis and breakdown, click here |
| Glossary: |
cyclic di-3′,5′-adenylate = c-di-AMP = c-di-adenylate = cyclic-bis(3′→5′) dimeric AMP |
| Other name(s): |
cyclic-di-AMP synthase; dacA (gene name); disA (gene name) |
| Systematic name: |
ATP:ATP adenylyltransferase (cyclizing) |
| Comments: |
Cyclic di-3′,5′-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signalling molecule [1].The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity [2]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Witte, G., Hartung, S., Buttner, K. and Hopfner, K.P. Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates. Mol. Cell 30 (2008) 167–178. [DOI] [PMID: 18439896] |
| 2. |
Woodward, J.J., Iavarone, A.T. and Portnoy, D.A. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 328 (2010) 1703–1705. [DOI] [PMID: 20508090] |
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| [EC 2.7.7.85 created 2013] |
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