The Enzyme Database

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EC 2.7.7.80     
Accepted name: molybdopterin-synthase adenylyltransferase
Reaction: ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP
For diagram of MoCo biosynthesis, click here
Glossary: small subunit of the molybdopterin synthase = molybdopterin-synthase sulfur-carrier protein = MoaD
Other name(s): MoeB; adenylyltransferase and sulfurtransferase MOCS3
Systematic name: ATP:molybdopterin-synthase adenylyltransferase
Comments: Adenylates the C-terminus of the small subunit of the molybdopterin synthase. This activation is required to form the thiocarboxylated C-terminus of the active molybdopterin synthase small subunit. The reaction occurs in prokaryotes and eukaryotes. In the human, the reaction is catalysed by the N-terminal domain of the protein MOCS3, which also includes a molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) C-terminal domain.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Leimkuhler, S., Wuebbens, M.M. and Rajagopalan, K.V. Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor. J. Biol. Chem. 276 (2001) 34695–34701. [PMID: 11463785]
2.  Matthies, A., Nimtz, M. and Leimkuhler, S. Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. Biochemistry 44 (2005) 7912–7920. [PMID: 15910006]
[EC 2.7.7.80 created 2011]
 
 


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