small subunit of the molybdopterin synthase = molybdopterin-synthase sulfur-carrier protein = MoaD
MoeB; adenylyltransferase and sulfurtransferase MOCS3
Adenylates the C-terminus of the small subunit of the molybdopterin synthase. This activation is required to form the thiocarboxylated C-terminus of the active molybdopterin synthase small subunit. The reaction occurs in prokaryotes and eukaryotes. In the human, the reaction is catalysed by the N-terminal domain of the protein MOCS3, which also includes a molybdopterin-synthase sulfurtransferase (EC 18.104.22.168) C-terminal domain.
Leimkuhler, S., Wuebbens, M.M. and Rajagopalan, K.V. Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor. J. Biol. Chem.276 (2001) 34695–34701. [DOI] [PMID: 11463785]
Matthies, A., Nimtz, M. and Leimkuhler, S. Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. Biochemistry44 (2005) 7912–7920. [DOI] [PMID: 15910006]