ExplorEnz: EC 2.7.7.70

Your query returned 1 entry. Printable version

2.7.7.70

Accepted name:

D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase

Reaction:

D-glycero-β-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-β-D-manno-heptose + diphosphate

Other name(s):

D-β-D-heptose 7-phosphate kinase/D-β-D-heptose 1-phosphate adenylyltransferase; D-glycero-D-manno-heptose-1β-phosphate adenylyltransferase; hldE (gene name); rfaE (gene name)

Systematic name:

ATP:D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase

Comments:

The bifunctional protein hldE includes D-glycero-β-D-manno-heptose-7-phosphate kinase and D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.1.167). The enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Valvano, M.A., Marolda, C.L., Bittner, M., Glaskin-Clay, M., Simon, T.L. and Klena, J.D. The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose. J. Bacteriol. 182 (2000) 488–497. [DOI] [PMID: 10629197]
2.	Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M.A. and Messner, P. Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli. J. Bacteriol. 184 (2002) 363–369. [DOI] [PMID: 11751812]
3.	Valvano, M.A., Messner, P. and Kosma, P. Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides. Microbiology 148 (2002) 1979–1989. [DOI] [PMID: 12101286]
4.	Wang, L., Huang, H., Nguyen, H.H., Allen, K.N., Mariano, P.S. and Dunaway-Mariano, D. Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB). Biochemistry 49 (2010) 1072–1081. [DOI] [PMID: 20050615]

[EC 2.7.7.70 created 2010]