| EC |
2.7.7.68 |
| Accepted name: |
2-phospho-L-lactate guanylyltransferase |
| Reaction: |
(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5′-guanosine + diphosphate |
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For diagram of coenzyme F420 biosynthesis, click here |
| Other name(s): |
cofC (gene name) (ambiguous) |
| Systematic name: |
GTP:2-phospho-L-lactate guanylyltransferase |
| Comments: |
This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor, in all methanogenic archaea. cf. EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase and EC 2.7.7.106, 3-phospho-(R)-glycerate guanylyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Grochowski, L.L., Xu, H. and White, R.H. Identification and characterization of the 2-phospho-L-lactate guanylyltransferase involved in coenzyme F420 biosynthesis. Biochemistry 47 (2008) 3033–3037. [DOI] [PMID: 18260642] |
| 2. |
Braga, D., Last, D., Hasan, M., Guo, H., Leichnitz, D., Uzum, Z., Richter, I., Schalk, F., Beemelmanns, C., Hertweck, C. and Lackner, G. Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420. ACS Chem. Biol. 14 (2019) 2088–2094. [PMID: 31469543] |
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| [EC 2.7.7.68 created 2010, revised 2019, modified 2020] |
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