The Enzyme Database

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EC 2.7.7.56     
Accepted name: tRNA nucleotidyltransferase
Reaction: tRNAn+1 + phosphate = tRNAn + a nucleoside diphosphate
Other name(s): phosphate-dependent exonuclease; RNase PH; ribonuclease PH
Systematic name: tRNA:phosphate nucleotidyltransferase
Comments: Brings about the final exonucleolytic trimming of the 3′-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3′-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 116412-36-3
References:
1.  Cudny, H. and Deutscher, M.P. 3′ processing of tRNA precursors in ribonuclease-deficient Escherichia coli. Development and characterization of an in vitro processing system and evidence for a phosphate requirement. J. Biol. Chem. 263 (1988) 1518–1523. [PMID: 3275667]
2.  Deutscher, M.P., Marshall, G.T. and Cudny, H. RNase PH: an Escherichia coli phosphate-dependent nuclease distinct from polynucleotide phosphorylase. Proc. Natl. Acad. Sci. USA 85 (1988) 4710–4714. [PMID: 2455297]
[EC 2.7.7.56 created 1992]
 
 


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