The Enzyme Database

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EC 2.7.7.50     
Accepted name: mRNA guanylyltransferase
Reaction: GTP + (5′)ppPur-mRNA = diphosphate + G(5′)pppPur-mRNA
Glossary: G(5′)pppPur-mRNA = mRNA containing a guanosine residue linked 5′ through three phosphates to the 5′ position of the terminal residue
Other name(s): mRNA capping enzyme; messenger RNA guanylyltransferase; Protein λ2
Systematic name: GTP:mRNA guanylyltransferase
Comments: The enzyme can also modify synthetic poly(A) and poly(G) to form the structures m7G(5′)pppAn and m7G(5′)pppGn.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 56941-23-2
References:
1.  Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. Modification of the 5′-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus. Proc. Natl. Acad. Sci. USA 72 (1975) 2525–2529. [PMID: 1058472]
2.  Groner, Y., Gilbao, E. and Aviv, H. Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates. Biochemistry 17 (1978) 977–982. [PMID: 629955]
3.  Itoh, N., Yamada, H., Kaziro, Y. and Mizumoto, K. Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization. J. Biol. Chem. 262 (1987) 1989–1995. [PMID: 3029058]
4.  Martin, S.A. and Moss, B. Modification of RNA by mRNA guanylyltransferase and mRNA(guanine-7-)methyltransferase from vaccinia virions. J. Biol. Chem. 250 (1975) 9330–9335. [PMID: 1194287]
5.  Martin, S.A., Paoletti, E. and Moss, B. Purification of mRNA guanylyltransferase and mRNA(guanine-7-)methyltransferase from vaccinia virions. J. Biol. Chem. 250 (1975) 9322–9329. [PMID: 1194286]
[EC 2.7.7.50 created 1981]
 
 


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