The Enzyme Database

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EC 2.7.7.24     
Accepted name: glucose-1-phosphate thymidylyltransferase
Reaction: dTTP + α-D-glucose 1-phosphate = diphosphate + dTDP-α-D-glucose
For diagram of 6-deoxyhexose biosynthesis, click here
Other name(s): glucose 1-phosphate thymidylyltransferase; dTDP-glucose synthase; dTDP-glucose pyrophosphorylase; thymidine diphosphoglucose pyrophosphorylase; thymidine diphosphate glucose pyrophosphorylase; TDP-glucose pyrophosphorylase
Systematic name: dTTP:α-D-glucose-1-phosphate thymidylyltransferase
Comments: Involved in the biosynthesis of L-rhamnose in bacteria.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9026-03-3
References:
1.  Kornfeld, S. and Glaser, L. The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose. J. Biol. Chem. 236 (1961) 1791–1794. [PMID: 13753209]
2.  Pazur, J.H. and Shuey, E.W. The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose. J. Biol. Chem. 236 (1961) 1780–1785. [PMID: 13733719]
3.  Zuccotti, S., Zanardi, D., Rosano, C., Sturla, L., Tonetti, M. and Bolognesi, M. Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase. J. Mol. Biol. 313 (2001) 831–843. [PMID: 11697907]
[EC 2.7.7.24 created 1965]
 
 


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