ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate
For diagram of the archaeal mevalonate pathway, click here
ATP:isopentenyl phosphate phosphotransferase
The enzyme is involved in the mevalonate pathway in Archaea . The activity has also been identified in the plant Mentha piperita (peppermint) . It is strictly specific for ATP but can use other phosphate acceptors such as dimethylallyl phosphate, geranyl phosphate, or fosfomycin.
Grochowski, L.L., Xu, H. and White, R.H. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. J. Bacteriol.188 (2006) 3192–3198. [DOI] [PMID: 16621811]
Lange, B.M. and Croteau, R. Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. Proc. Natl. Acad. Sci. USA96 (1999) 13714–13719. [DOI] [PMID: 10570138]
Chen, M. and Poulter, C.D. Characterization of thermophilic archaeal isopentenyl phosphate kinases. Biochemistry49 (2010) 207–217. [DOI] [PMID: 19928876]
Mabanglo, M.F., Schubert, H.L., Chen, M., Hill, C.P. and Poulter, C.D. X-ray structures of isopentenyl phosphate kinase. ACS Chem. Biol.5 (2010) 517–527. [DOI] [PMID: 20402538]