| EC |
2.7.4.26 |
| Accepted name: |
isopentenyl phosphate kinase |
| Reaction: |
ATP + 3-methylbut-3-en-1-yl phosphate = ADP + 3-methylbut-3-en-1-yl diphosphate |
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For diagram of the archaeal mevalonate pathway, click here |
| Other name(s): |
ATP:isopentenyl phosphate phosphotransferase |
| Systematic name: |
ATP:3-methylbut-3-en-1-yl-phosphate phosphotransferase |
| Comments: |
The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as prenyl phosphate, geranyl phosphate, or fosfomycin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Grochowski, L.L., Xu, H. and White, R.H. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. J. Bacteriol. 188 (2006) 3192–3198. [DOI] [PMID: 16621811] |
| 2. |
Lange, B.M. and Croteau, R. Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. Proc. Natl. Acad. Sci. USA 96 (1999) 13714–13719. [DOI] [PMID: 10570138] |
| 3. |
Chen, M. and Poulter, C.D. Characterization of thermophilic archaeal isopentenyl phosphate kinases. Biochemistry 49 (2010) 207–217. [DOI] [PMID: 19928876] |
| 4. |
Mabanglo, M.F., Schubert, H.L., Chen, M., Hill, C.P. and Poulter, C.D. X-ray structures of isopentenyl phosphate kinase. ACS Chem. Biol. 5 (2010) 517–527. [DOI] [PMID: 20402538] |
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| [EC 2.7.4.26 created 2012] |
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