ExplorEnz: EC 2.7.4.22

Your query returned 1 entry. Printable version

2.7.4.22

Accepted name:

UMP kinase

Reaction:

ATP + UMP = ADP + UDP

Other name(s):

uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA

Systematic name:

ATP:UMP phosphotransferase

Comments:

This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9036-23-1

References:

1.	Serina, L., Blondin, C., Krin, E., Sismeiro, O., Danchin, A., Sakamoto, H., Gilles, A.M. and Bârzu, O. Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP. Biochemistry 34 (1995) 5066–5074. [PMID: 7711027]
2.	Marco-Marín, C., Gil-Ortiz, F. and Rubio, V. The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis. J. Mol. Biol. 352 (2005) 438–454. [DOI] [PMID: 16095620]

[EC 2.7.4.22 created 2006]