The Enzyme Database

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EC 2.7.11.3     
Accepted name: dephospho-[reductase kinase] kinase
Reaction: ATP + dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} = ADP + {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase}
Other name(s): AMP-activated kinase; AMP-activated protein kinase kinase; hydroxymethylglutaryl coenzyme A reductase kinase kinase; hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating); reductase kinase; reductase kinase kinase; STK30
Systematic name: ATP:dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} phosphotransferase
Comments: The enzyme is activated by AMP and is specific for its substrate. Phosphorylates and activates EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, that has been inactivated by EC 3.1.3.16, protein-serine/threonine phosphatase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 72060-33-4
References:
1.  Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc. Natl. Acad. Sci. USA 76 (1979) 4375–4379. [PMID: 291971]
2.  Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M. Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation. Biochem. Biophys. Res. Commun. 81 (1978) 1268–1277. [PMID: 666819]
3.  Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase. J. Biol. Chem. 260 (1985) 1682–1687. [PMID: 3155737]
4.  Clarke, P.R. and Hardie, D.G. Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J. 9 (1990) 2439–2446. [PMID: 2369897]
5.  Sato, R., Goldstein, J.L. and Brown, M.S. Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. Proc. Natl. Acad. Sci. USA 90 (1993) 9261–9265. [PMID: 8415689]
[EC 2.7.11.3 created 1984 as EC 2.7.1.110, transferred 2005 to EC 2.7.11.3]
 
 


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