The Enzyme Database

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EC 2.7.11.28     
Accepted name: tropomyosin kinase
Reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin
Other name(s): tropomyosin kinase (phosphorylating); STK
Systematic name: ATP:tropomyosin O-phosphotransferase
Comments: The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 90804-56-1
References:
1.  deBelle, I. and Mak, A.S. Isolation and characterization of tropomyosin kinase from chicken embryo. Biochim. Biophys. Acta 925 (1987) 17–26. [PMID: 3593768]
2.  Montgomery, K. and Mak, A.S. In vitro phosphorylation of tropomyosin by a kinase from chicken embryo. J. Biol. Chem. 259 (1984) 5555–5560. [PMID: 6325440]
3.  Watson, M.H., Taneja, A.K., Hodges, R.S. and Mak, A.S. Phosphorylation of α α- and β β-tropomyosin and synthetic peptide analogues. Biochemistry 27 (1988) 4506–4512. [PMID: 3166994]
[EC 2.7.11.28 created 1990 as EC 2.7.1.132, transferred 2005 to EC 2.7.11.28]
 
 


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