Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
Johnson, D.G. and Walker, C.L. Cyclins and cell cycle checkpoints. Annu. Rev. Pharmacol. Toxicol.39 (1999) 295–312. [DOI] [PMID: 10331086]
Pan, Z.Q., Amin, A. and Hurwitz, J. Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities. J. Biol. Chem.268 (1993) 20443–20451. [PMID: 8397207]
Yee, A., Wu, L., Liu, L., Kobayashi, R., Xiong, Y. and Hall, F.L. Biochemical characterization of the human cyclin-dependent protein kinase activating kinase. Identification of p35 as a novel regulatory subunit. J. Biol. Chem.271 (1996) 471–477. [DOI] [PMID: 8550604]
[EC 188.8.131.52 created 2005 (EC 184.108.40.206 part-incorporated 2005)]