| EC |
2.7.11.22 |
| Accepted name: |
cyclin-dependent kinase |
| Reaction: |
ATP + a protein = ADP + a phosphoprotein |
| Other name(s): |
Bur1; Bur1 Cdk; Cak1; Cak1p; cdc2; cdc2 kinase; Cdc28p; CDK; cdk-activating kinase; Cdk-activating protein kinase; cdk1; cdk2; Cdk2; cdk3; cdk4; cdk5; cdk6; cdk7; cdk8; cdk9; cyclin A-activated cdc2; cyclin A-activated cdk2; cyclin D-cdk6 kinase; cyclin D-dependent kinase; cyclin E kinase; cyclin-A associated kinase; cyclin-dependent kinase 6; cyclin-dependent kinase-2; cyclin-dependent kinase-4; cyclin-dependent protein kinase activating kinase; cyk; D-type cyclin kinase; nclk; neuronal cdc2-like kinase; PCTAIRE-1; STK25 |
| Systematic name: |
ATP:cyclin phosphotransferase |
| Comments: |
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Johnson, D.G. and Walker, C.L. Cyclins and cell cycle checkpoints. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 295–312. [DOI] [PMID: 10331086] |
| 2. |
Pan, Z.Q., Amin, A. and Hurwitz, J. Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities. J. Biol. Chem. 268 (1993) 20443–20451. [PMID: 8397207] |
| 3. |
Yee, A., Wu, L., Liu, L., Kobayashi, R., Xiong, Y. and Hall, F.L. Biochemical characterization of the human cyclin-dependent protein kinase activating kinase. Identification of p35 as a novel regulatory subunit. J. Biol. Chem. 271 (1996) 471–477. [DOI] [PMID: 8550604] |
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| [EC 2.7.11.22 created 2005 (EC 2.7.1.37 part-incorporated 2005)] |
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