| EC |
2.7.11.20 |
| Accepted name: |
elongation factor 2 kinase |
| Reaction: |
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate |
| Other name(s): |
Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19 |
| Systematic name: |
ATP:[elongation factor 2] phosphotransferase |
| Comments: |
Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 116283-83-1 |
| References: |
| 1. |
Mitsui, K., Brady, M., Palfrey, H.C. and Nairn, A.C. Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas. J. Biol. Chem. 268 (1993) 13422–13433. [PMID: 8514778] |
| 2. |
Hincke, M.T. and Nairn, A.C. Phosphorylation of elongation factor 2 during Ca2+-mediated secretion from rat parotid acini. Biochem. J. 282 (1992) 877–882. [PMID: 1372803] |
| 3. |
Knebel, A., Morrice, N. and Cohen, P. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. EMBO J. 20 (2001) 4360–4369. [DOI] [PMID: 11500363] |
| 4. |
Sans, M.D., Xie, Q. and Williams, J.A. Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini. Biochem. Biophys. Res. Commun. 319 (2004) 144–151. [DOI] [PMID: 15158453] |
| 5. |
Browne, G.J., Finn, S.G. and Proud, C.G. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J. Biol. Chem. 279 (2004) 12220–12231. [DOI] [PMID: 14709557] |
| 6. |
Ryazanov, A.G. Elongation factor-2 kinase and its newly discovered relatives. FEBS Lett. 514 (2002) 26–29. [DOI] [PMID: 11904175] |
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| [EC 2.7.11.20 created 2005] |
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