The Enzyme Database

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EC 2.7.1.78     
Accepted name: polynucleotide 5′-hydroxyl-kinase
Reaction: ATP + 5′-dephospho-DNA = ADP + 5′-phospho-DNA
Other name(s): ATP:5′-dephosphopolynucleotide 5′-phosphatase; PNK; polynucleotide 5′-hydroxyl kinase (phosphorylating); 5′-hydroxyl polynucleotide kinase; 5′-hydroxyl polyribonucleotide kinase; 5′-hydroxyl RNA kinase; DNA 5′-hydroxyl kinase; DNA kinase; polynucleotide kinase; polynucleotide 5′-hydroxy-kinase
Systematic name: ATP:5′-dephosphopolynucleotide 5′-phosphotransferase
Comments: Also acts on 5′-dephospho-RNA 3′-mononucleotides.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37211-65-7
References:
1.  Novogrodsky, A. and Hurwitz, J. The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5′-hydroxyl termini. J. Biol. Chem. 241 (1966) 2923–2932. [PMID: 4287929]
2.  Novogrodsky, A., Tal, M., Traub, A. and Hurwitz, J. The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5′-hydroxyl polynucleotide kinase. J. Biol. Chem. 241 (1966) 2933–2943. [PMID: 4287930]
[EC 2.7.1.78 created 1972]
 
 


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