The Enzyme Database

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EC 2.7.1.40     
Accepted name: pyruvate kinase
Reaction: ATP + pyruvate = ADP + phosphoenolpyruvate
For diagram of the Entner-Doudoroff pathway, click here
Other name(s): phosphoenolpyruvate kinase; phosphoenol transphosphorylase
Systematic name: ATP:pyruvate 2-O-phosphotransferase
Comments: UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-59-6
References:
1.  Boyer, P.D. Pyruvate kinase. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 6, Academic Press, New York, 1962, pp. 95–113.
2.  Kornberg, A. and Pricer, W.E. Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. J. Biol. Chem. 193 (1951) 481–495. [PMID: 14907737]
3.  Kubowitz, F. and Ott, P. Isolierung von Gärungsfermenten aus menschlichen Muskeln. Biochem. Z. 317 (1944) 193–203.
4.  Strominger, J.L. Enzymatic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. Biochim. Biophys. Acta 16 (1955) 616–618. [PMID: 14389299]
5.  Tietz, A. and Ochoa, S. "Fluorokinase" and pyruvic kinase. Arch. Biochem. Biophys. 78 (1958) 477–493. [PMID: 13618030]
[EC 2.7.1.40 created 1961]
 
 


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