The Enzyme Database

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EC 2.7.1.21     
Accepted name: thymidine kinase
Reaction: ATP + thymidine = ADP + dTMP
Glossary: dTMP = thymidine 5′-phosphate
Other name(s): thymidine kinase (phosphorylating); 2′-deoxythymidine kinase; deoxythymidine kinase (phosphorylating)
Systematic name: ATP:thymidine 5′-phosphotransferase
Comments: Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP—thymidine kinase), EC 2.7.1.118 (ADP—thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9002-06-6
References:
1.  Falke, D., Labenz, J., Brauer, D. and Muller, W.E.G. Adenosine diphosphate: thymidine 5′-phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus-induced deoxypyrimidine kinase. Biochim. Biophys. Acta 708 (1982) 99–103. [PMID: 6293576]
2.  Kizer, D.E. and Holman, L. Purification and properties of thymidine kinase from regenerating rat liver. Biochim. Biophys. Acta 350 (1974) 193–200. [PMID: 4407348]
3.  Okazaki, R. and Kornberg, A. Deoxythymidine kinase of Escherichia coli. I. Purification and some properties of the enzyme. J. Biol. Chem. 239 (1964) 269–274. [PMID: 14114853]
[EC 2.7.1.21 created 1961, deleted 1972, reinstated 1976 (EC 2.7.1.75 created 1972, incorporated 1976)]
 
 


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