The Enzyme Database

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EC 2.7.1.185     
Accepted name: mevalonate 3-kinase
Reaction: ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate
For diagram of the archaeal mevalonate pathway, click here
Other name(s): ATP:(R)-MVA 3-phosphotransferase
Systematic name: ATP:(R)-mevalonate 3-phosphotransferase
Comments: Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Vinokur, J.M., Korman, T.P., Cao, Z. and Bowie, J.U. Evidence of a novel mevalonate pathway in archaea. Biochemistry 53 (2014) 4161–4168. [PMID: 24914732]
2.  Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T. and Hemmi, H. (R)-Mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. J. Biol. Chem. 289 (2014) 15957–15967. [PMID: 24755225]
[EC 2.7.1.185 created 2014]
 
 


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