ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate
For diagram of the archaeal mevalonate pathway, click here
Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 18.104.22.168) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 22.214.171.124, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.
Vinokur, J.M., Korman, T.P., Cao, Z. and Bowie, J.U. Evidence of a novel mevalonate pathway in archaea. Biochemistry53 (2014) 4161–4168. [DOI] [PMID: 24914732]
Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T. and Hemmi, H. (R)-Mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. J. Biol. Chem.289 (2014) 15957–15967. [DOI] [PMID: 24755225]