The Enzyme Database

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EC 2.7.1.177     
Accepted name: L-threonine kinase
Reaction: ATP + L-threonine = ADP + O-phospho-L-threonine
For diagram of corrin biosynthesis (part 6), click here
Other name(s): PduX
Systematic name: ATP:L-threonine O3-phosphotransferase
Comments: The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Fan, C. and Bobik, T.A. The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis. J. Biol. Chem. 283 (2008) 11322–11329. [PMID: 18308727]
2.  Fan, C., Fromm, H.J. and Bobik, T.A. Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica. J. Biol. Chem. 284 (2009) 20240–20248. [PMID: 19509296]
[EC 2.7.1.177 created 2012]
 
 


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