EC |
2.7.1.168 |
Accepted name: |
D-glycero-α-D-manno-heptose-7-phosphate kinase |
Reaction: |
D-glycero-α-D-manno-heptose 7-phosphate + ATP = D-glycero-α-D-manno-heptose 1,7-bisphosphate + ADP |
Other name(s): |
D-α-D-heptose-7-phosphate kinase; hdda (gene name) |
Systematic name: |
ATP:D-glycero-α-D-manno-heptose 7-phosphate 1-phosphotransferase |
Comments: |
The enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein in Gram-positive bacteria. The enzyme is specific for the α-anomer. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Kneidinger, B., Graninger, M., Puchberger, M., Kosma, P. and Messner, P. Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose. J. Biol. Chem. 276 (2001) 20935–20944. [DOI] [PMID: 11279237] |
2. |
Valvano, M.A., Messner, P. and Kosma, P. Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides. Microbiology 148 (2002) 1979–1989. [DOI] [PMID: 12101286] |
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[EC 2.7.1.168 created 2010] |
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