| EC |
2.7.1.164 |
| Accepted name: |
O-phosphoseryl-tRNASec kinase |
| Reaction: |
ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec |
| Other name(s): |
PSTK; phosphoseryl-tRNA[Ser]Sec kinase; phosphoseryl-tRNASec kinase |
| Systematic name: |
ATP:L-seryl-tRNASec O-phosphotransferase |
| Comments: |
In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 91273-83-5 |
| References: |
| 1. |
Carlson, B.A., Xu, X.M., Kryukov, G.V., Rao, M., Berry, M.J., Gladyshev, V.N. and Hatfield, D.L. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Proc. Natl. Acad. Sci. USA 101 (2004) 12848–12853. [DOI] [PMID: 15317934] |
| 2. |
Sherrer, R.L., O'Donoghue, P. and Soll, D. Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation. Nucleic Acids Res. 36 (2008) 1247–1259. [DOI] [PMID: 18174226] |
| 3. |
Khangulov, S.V., Gladyshev, V.N., Dismukes, G.C. and Stadtman, T.C. Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer. Biochemistry 37 (1998) 3518–3528. [DOI] [PMID: 9521673] |
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| [EC 2.7.1.164 created 2009] |
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