The Enzyme Database

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EC 2.7.1.163     
Accepted name: hygromycin B 4-O-kinase
Reaction: ATP + hygromycin B = ADP + 4-O-phosphohygromycin B
Other name(s): hygromycin-B kinase (ambiguous)
Systematic name: ATP:hygromycin-B 4-O-phosphotransferase
Comments: Phosphorylates the antibiotic hygromycin B. Whereas the enzyme from Streptomyces hygroscopicus (EC 2.7.1.119; hygromycin-B 7′′-O-kinase) catalyses the formation of 7′′-O-phosphohygromycin B, this enzyme, found in Escherichia coli carrying a plasmid conferring resistance to hygromycin-B, forms 4-O-phosphohygromycin B.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Rao, R.N., Allen, N.E., Hobbs, J.N., Jr., Alborn, W.E., Jr., Kirst, H.A. and Paschal, J.W. Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli. Antimicrob. Agents Chemother. 24 (1983) 689–695. [PMID: 6318654]
[EC 2.7.1.163 created 2009]
 
 


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