ExplorEnz: EC 2.7.1.151

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2.7.1.151

Accepted name:

inositol-polyphosphate multikinase

Reaction:

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction)
(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

For diagram of myo-inositol-phosphate metabolism, click here

Other name(s):

IpK2; IP₃/IP4 6-/3-kinase; IP₃/IP4 dual-specificity 6-/3-kinase; IpmK; ArgRIII; AtIpk2α; AtIpk2β; inositol polyphosphate 6-/3-/5-kinase

Systematic name:

ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase

Comments:

This enzyme also phosphorylates Ins(1,4,5)P₃ to Ins(1,3,4,5)P₄, Ins(1,3,4,5)P₄ to Ins(1,3,4,5,6)P₅, and Ins(1,3,4,5,6)P₄ to Ins(PP)P₄, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P₄ and Ins(1,2,3,4,6)P₅ at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP₆), respectively [3]. Yeast produce InsP₆ from Ins(1,4,5)P₃ by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9077-69-4

References:

1.	Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H. Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr. Biol. 9 (1999) 1323–1326. [DOI] [PMID: 10574768]
2.	Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D. A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science 287 (2000) 2026–2029. [DOI] [PMID: 10720331]
3.	Stevenson-Paulik, J., Odom, A.R. and York, J.D. Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. J. Biol. Chem. 277 (2002) 42711–42718. [DOI] [PMID: 12226109]
4.	Verbsky, J.W., Chang, S.C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W. The pathway for the production of inositol hexakisphosphate in human cells. J. Biol. Chem. 280 (2005) 1911–1920. [DOI] [PMID: 15531582]

[EC 2.7.1.151 created 2002, modified 2006]