The Enzyme Database

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EC 2.7.1.130     
Accepted name: tetraacyldisaccharide 4′-kinase
Reaction: ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl}-(1→6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl phosphate} = ADP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-β-D-glucosaminyl}-(1→6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl phosphate}
For diagram of lipid IVA biosynthesis, click here
Other name(s): lipid-A 4′-kinase
Systematic name: ATP:2,2′,3,3′-tetrakis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl-(1→6)-α-D-glucosaminyl-phosphate 4′-O-phosphotransferase
Comments: Involved with EC 2.3.1.129 (acyl-[acyl-carrier- protein]—UDP-N-acetylglucosamine O-acyltransferase) and EC 2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 107309-06-8
References:
1.  Ray, B.L. and Raetz, C.R.H. The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4′-phosphate of lipid A. J. Biol. Chem. 262 (1987) 1122–1128. [PMID: 3027079]
[EC 2.7.1.130 created 1990]
 
 


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