The Enzyme Database

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EC 2.7.1.1     
Accepted name: hexokinase
Reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate
Other name(s): hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase
Systematic name: ATP:D-hexose 6-phosphotransferase
Comments: D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 9001-51-8
References:
1.  Bailey, K. and Webb, E.C. Purification of yeast hexokinase and its reaction with ββ′-dichlorodiethyl sulphide. Biochem. J. 42 (1948) 60–68. [PMID: 16748250]
2.  Berger, L., Slein, M.W., Colowick, S.P. and Cori, C.F. Isolation of hexokinase from baker's yeast. J. Gen. Physiol. 29 (1946) 379–391.
3.  Kunitz, M. and McDonald, M.R. Crystalline hexokinase (heterophosphatase). Method of isolation and properties. J. Gen. Physiol. 29 (1946) 393–412.
4.  Pollard-Knight, D. and Cornish-Bowden, A. Mechanism of liver glucokinase. Mol. Cell. Biochem. 44 (1982) 71–80. [PMID: 7048063]
5.  Ureta, T., Radojkovic, J., Lagos, R., Guixe, V. and Núñnez, L. Phylogenetic and ontogenetic studies of glucose phosphorylating isozymes of vertebrates. Arch. Biol. Med. Exp. 12 (1979) 587–604. [PMID: 233226]
6.  Cárdenas, M.L., Rabajille, E. and Niemeyer, H. Fructose: A good substrate for rat-liver 'glucokinase' (hexokinase D). Biochem. J. 222 (1984) 363–370. [PMID: 6477520]
[EC 2.7.1.1 created 1961]
 
 


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