The Enzyme Database

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EC 2.6.99.3     
Accepted name: O-ureido-L-serine synthase
Reaction: O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate
Glossary: O-ureido-L-serine = (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate
O-acetyl-L-serine = O3-acetyl-L-serine = (2S)-3-acetyloxy-2-aminopropanoic acid
Other name(s): dcsD (gene name)
Systematic name: O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase
Comments: The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Kumagai, T., Koyama, Y., Oda, K., Noda, M., Matoba, Y. and Sugiyama, M. Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae. Antimicrob. Agents Chemother. 54 (2010) 1132–1139. [PMID: 20086163]
2.  Uda, N., Matoba, Y., Kumagai, T., Oda, K., Noda, M. and Sugiyama, M. Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway. Antimicrob. Agents Chemother. 57 (2013) 2603–2612. [PMID: 23529730]
[EC 2.6.99.3 created 2013]
 
 


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