ExplorEnz: EC 2.6.1.94

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2.6.1.94

Accepted name:

2′-deamino-2′-hydroxyneamine transaminase

Reaction:

2′-deamino-2′-hydroxyneamine + 2-oxoglutarate = 2′-deamino-2′-hydroxy-6′-dehydroparomamine + L-glutamate

Other name(s):

kacL (gene name)

Systematic name:

2′-deamino-2′-hydroxyneamine:2-oxoglutarate aminotransferase

Comments:

The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of kanamycin A and kanamycin D. The enzyme, characterized from the bacterium Streptomyces kanamyceticus, can also catalyse EC 2.6.1.93, neamine transaminase.

Links to other databases:

BRENDA, EXPASY, KEGG, METACYC

References:

1.	Park, J.W., Park, S.R., Nepal, K.K., Han, A.R., Ban, Y.H., Yoo, Y.J., Kim, E.J., Kim, E.M., Kim, D., Sohng, J.K. and Yoon, Y.J. Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. Nat. Chem. Biol. 7 (2011) 843–852. [PMID: 21983602]

[EC 2.6.1.94 created 2012]