The enzyme is composed of two parts, PabA and PabB. In the absence of PabA and glutamine, PabB converts ammonia and chorismate into 4-amino-4-deoxychorismate (in the presence of Mg2+). PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. This enzyme is coupled with EC 220.127.116.11, aminodeoxychorismate lyase, to form 4-aminobenzoate.
Ye, Q.Z., Liu, J. and Walsh, C.T. p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. Proc. Natl. Acad. Sci. USA87 (1990) 9391–9395. [DOI] [PMID: 2251281]
Viswanathan, V.K., Green, J.M. and Nichols, B.P. Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli. J. Bacteriol.177 (1995) 5918–5923. [DOI] [PMID: 7592344]
[EC 18.104.22.168 created 2003 as EC 22.214.171.124, transferred 2007 to EC 126.96.36.199]