ExplorEnz: EC 2.6.1.77

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2.6.1.77

Accepted name:

taurine—pyruvate aminotransferase

Reaction:

taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde

For diagram of reaction, click here

Glossary:

taurine = 2-aminoethanesulfonate
hypotaurine = 2-aminoethanesulfinate
2-sulfoacetaldehyde = 2-oxoethanesulfonate
2-sulfinoacetaldehyde = 2-oxoethanesulfinate

Other name(s):

Tpa

Systematic name:

taurine:pyruvate aminotransferase

Comments:

The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5′-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. β-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine—2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 51901-18-9

References:

1.	Laue, H. and Cook, A.M. Biochemical and molecular characterization of taurine:pyruvate transaminase from the anaerobe Bilophila wadsworthia. Eur. J. Biochem. 267 (2000) 6841–6848. [DOI] [PMID: 11082195]
2.	Cook, A.M. and Denger, K. Dissimilation of the C₂ sulfonates. Arch. Microbiol. 179 (2002) 1–6. [DOI] [PMID: 12471498]
3.	Masepohl, B., Fuhrer, F. and Klipp, W. Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source. FEMS Microbiol. Lett. 205 (2001) 105–111. [DOI] [PMID: 11728723]
4.	Felux, A.K., Denger, K., Weiss, M., Cook, A.M. and Schleheck, D. Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth. J. Bacteriol. 195 (2013) 2921–2930. [DOI] [PMID: 23603744]

[EC 2.6.1.77 created 2003]