The Enzyme Database

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EC 2.6.1.74     
Accepted name: cephalosporin-C transaminase
Reaction: (7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate = cephalosporin C + 2-oxoglutarate
For diagram of cephalosporin biosynthesis, click here
Glossary: cephalosporin C = (7R)-7-(5-carboxy-5-oxopentanamido)cephalosporanate
Other name(s): cephalosporin C aminotransferase; L-alanine:cephalosporin-C aminotransferase
Systematic name: cephalosporin-C:2-oxoglutarate aminotransferase
Comments: A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 122096-91-7
References:
1.  Aretz, W. and Sauber, K. Novel D-amino acid transaminase. Ann. N.Y. Acad. Sci. 542 (1988) 366–370. [PMID: 3228235]
[EC 2.6.1.74 created 1992, modified 2005]
 
 


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