ExplorEnz: EC 2.6.1.7

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2.6.1.7

Accepted name:

kynurenine—oxoglutarate transaminase

Reaction:

L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H₂O (overall reaction)
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
(1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H₂O (spontaneous)

For diagram of EC 2.6.1, click here and for diagram of tryptophan catabolism, click here

Glossary:

kynurenine = 2-amino-4-(2-aminophenyl)-4-oxobutanoic acid = 3-anthraniloylalanine
kynurenate = 4-hydroxyquinoline-2-carboxylate

Other name(s):

kynurenine transaminase (cyclizing); kynurenine 2-oxoglutarate transaminase; kynurenine aminotransferase; L-kynurenine aminotransferase

Systematic name:

L-kynurenine:2-oxoglutarate aminotransferase

Comments:

A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-38-0

References:

1.	Jakoby, W.B. and Bonner, D.M. Kynurenine transaminase from Neurospora. J. Biol. Chem. 221 (1956) 689–695. [PMID: 13357462]
2.	Mason, M. Kynurenine transaminase of rat kidney: a study of coenzyme dissociation. J. Biol. Chem. 227 (1957) 61–68. [PMID: 13449053]
3.	Noguchi, T., Minatogawa, Y., Okuno, E., Nakatani, M. and Morimoto, M. Purification and characterization of kynurenine—2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats. Biochem. J. 151 (1975) 399–406. [DOI] [PMID: 1218085]
4.	Han, Q., Cai, T., Tagle, D.A., Robinson, H. and Li, J. Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. Biosci Rep 28 (2008) 205–215. [DOI] [PMID: 18620547]
5.	Han, Q., Robinson, H., Cai, T., Tagle, D.A. and Li, J. Biochemical and structural properties of mouse kynurenine aminotransferase III. Mol. Cell Biol. 29 (2009) 784–793. [DOI] [PMID: 19029248]

[EC 2.6.1.7 created 1961, modified 1983]